BIOMARKED is the coordination center of a network of laboratories of Ghent University with focus and expertise in identification and validation of biomarkers for early diagnosis, prognosis/risk stratification and prediction towards therapy in cancer, inflammatory diseases and metabolic diseases. It combines multidisciplinary expertise of innovative technology platforms (f.e. next-generation genome analysis, -omics expertise) with clinical validation teams and strong expertise in bioinformatics.
Promotor of the consortium: prof dr ir Wim Van Criekinge
Technology Developer: dr Daisy Flamez
Biomarked combines expertise of 15 research teams in different faculties of Ghent University with active members in 4 spearheads of Ghent University and University Hospital:
Faculty of Bioscience Engineering :
– Laboratory of bioinformatics and computational genomics (Biobix): prof W. Van Criekinge (promotor-coordinator BIOMARKED) and partner of the spearhead informatics (N2N) http://www.nucleotides2networks.be/: expertise in bioinformatics, statistics, whole methylome and targeted methylomics, transcriptomics, biomarkers for diagnose, prognose and risk stratifcation in cancer, immune disorders, infectious diseases http://gete.ugent.be/groups/bioinformatics/
– Laboratory of Biochemistry and Glycobiology: prof Els Vandamme: expertise in glycomics, lectins http://www.molecularbiotechnology.ugent.be/group-research-5.html
Faculty of Medicine and Health Sciences :
– Center of Medical Genetics prof F. Speleman and prof J. Vandesompele: focus on hematological malignancies, neuroblastoma, melanoma, bioinformatics, NGS targeted resequencing, miRNA/lncRNA analysis
– Laboratory of Experimental Cancer Research: focus on breast cancer and colorectal cancer prof M. Bracke and prof O. De Wever http://www.ecnurad.ugent.be/LECR/en/expertise.html
– Department Medical Oncology: prof S Van Belle and prof V. Coquyt
– Spearhead Oncology UZGent focus Prognostic biomarkers in early breast cancer: therapeutic opportunities Prof V. Coquyt and prof S. Van Belle (Medical Oncology), Prof R. Van Den Broecke & Prof G. Brams (Gynaecology), Prof. L Libbrecht (Pathology), Prof. M. Bracke & Prof. O. De Wever (Experimental Cancer Research)
– Radiotherapy Department: head of department prof W. De Neve
– Department Pathology: prof M. Praet
– Laboratory of Biomedical Physics and Radioprotection: prof H. Thierens
– HIV reference center: prof L. Vandekerckhove
– Gynaecology: prof H. Depypere
– Laboratory of Translational Research in Obstructive Pulmonary Diseases: prof G. Brusselle: focus on COPD http://www.ugent.be/ge/inwgen/nl/onderzoek/pneumologie/overzicht.htm
– Laboratory of Upper Airway Research Lab: prof C. Bachert: focus on astma http://www.nko.ugent.be/drupal/
Faculty of Pharmacy :
– Laboratory of Pharmaceutical Biotechnology: prof D. Deforce: expertise in metagenomics, HPV research, transcriptomics , founding partner of NXTGNT http://www.ugent.be/fw/en/research/pharmaceutics/biotechnology
NXTGNT Center in Pharmaco(epi)genomics http://www.nxtgnt.com/wordpress/ expertise in captured methylated DNA sequencing: genome wide MBD sequencing or targeted reduced bisulfite sequencing, transcriptomics, bioinformatics, personalized medicine for patient stratification towards therapy, discovery of new biomarkers for diagnosis
IRC Inflammation research center – Laboratory for Medical Biotechnology prof N. Callewaert: http://www.dmbr.ugent.be/index.php?id=nicocallewaerthome (partner in spearhead Medical Biotechnology for biomedical research, diagnosis and therapy: Glycomics-based diagnostics development to enable novel approaches to study, diagnose and treat immune-system related disease and expertise in biological systems engineering (synthetic biology), Glycoconjugate engineering, High-throughput glycan profiling (glycomics), Mycobacterium-host interactions
Department of Biochemistry and VIB proteomics expertise center – prof K. Gevaert http://www.vib.be/en/research/scientists/Pages/kris-gevaert-Lab.aspx (partner in spearhead bioinformatics N2N and spearhead Group-ID) focuses on the development and applications of proprietary peptide-centric and mass spectrometry-driven proteomics techniques: COFRADIC – gel-free proteomics – bioinformatics – protein processing – protein modification